Greek fourth seed and Monte Carlo winner Stefanos Tsitsipas will play Daniel Elahi Galan of Colombia in his first match at the US Open on Tuesday.
The tournament remains a thorn in the side of the Greek champion, who has never passed the third round at Flushing Meadows. The 24-year-old Cincinnati runner-up appears rejuvenated following the addition of former Australian world No 8 Mark Philippoussis to his coaching team.
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Top seed Daniil Medvedev will open his US Open title defence on Monday against American Stefan Kozlov.
A year after attaining the semifinals of the US Open, No 3 Maria Sakkari of Greece will face Germany’s Tatjana Maria in the women’s singles. A two-time Grand Slam finalist, the 27-year-old hopes to bounce back from a relatively poor season.